Sunday, April 10, 2016

LAMA and LABA combination Treatment for COPD is more Effective than Monotherapy


Treatment of chronic obstructive pulmonary disease (COPD) has always been a challenge to the physician.
According to a publication, [Published online ahead of print March 3, 2016]. Chest. doi:10.1016/j.chest.2016.02.646, “A systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable chronic obstructive pulmonary disease” by Calzetta L, Rogliani P, Matera MG, Cazzola M., dual bronchodilation with Long-acting Muscarinic Antagonists/Long-acting Beta Agonists (LAMA/LABA) for the treatment of stable chronic obstructive pulmonary disease (COPD) is more effective than a LAMA or a LABA alone
Dual bronchodilation with Long-acting Muscarinic Antagonists/Long-acting Beta Agonists (LAMA/LABA) for the treatment of stable chronic obstructive pulmonary disease (COPD) is more effective than a LAMA or a LABA alone, regardless of the drugs used.
Enlarged view of lung tissue showing the diffe...
Enlarged view of lung tissue showing the difference between healthy lung and COPD (Photo credit: Wikipedia)
This according to a review and meta-analysis of 23,168 COPD patients (combinations n=10,328; monocomponents n=12,840) who participated in trials that lasted at least 3 months. Researchers found:
• All LAMA/LABA combinations were always more effective than the LAMA or LABA alone in terms of improvement in trough FEV1.
• There was a gradient of effectiveness among the currently available LAMA/LABA fixed-dose combinations, although there was not a significant difference among them.
• LAMA/LABA combinations also improved both quality of life scores, and did not increase the cardiovascular risk when compared with monocomponents.
There are currently 3 FDA approved LABA/LAMA combination inhalers:
• Umeclidinium bromide and vilanterol (Anoro-GSK).
Glycopyrronium bromide and indacaterol (Ultibro-Novartis).
Tiotropium and olodaterol (Stiolto Respimat-Boehringer Ingelheim Pharmaceuticals).


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