Once Daily Combination Drug Linagliptin and Metformin approved by FDA for T2DM

The FDA has approved once-daily Jentadueto XR (linagliptin and metformin hydrochloride extended-release) tablets from Eli Lilly and Boehringer Ingelheim for the treatment of type 2 diabetes (T2D) in adults.

English: The blue circle is the global symbol for diabetes, introduced by the International Diabetes Federation with the aim of giving diabetes a common identity, supporting existing efforts to raise awareness of diabetes and placing the diabetes epidemic firmly in the public spotlight. (Photo credit: Wikipedia)

Indications: Jentadueto XR is a dipeptidyl peptidase-4 (DPP-4) inhibitor and biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2D mellitus when treatment with both linagliptin and metformin is appropriate.

Dosage and administration: Individualize the starting dose of Jentadueto XR based on the patient’s current regimen. Do not exceed a total daily dose of linagliptin 5 mg and metformin 2000 mg. Give once daily with a meal.

Adverse reactions: The most common side effects include stuffy or runny nose, sore throat, and diarrhoea.

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DPP-4 Inhibitora like Saxagliptin and Alogliptin may increase the Risk of Heart Failure

Diabetes drugs containing saxagliptin (Onglyza) and alogliptin (Nesina) may increase the risk of heart failure, the US FDA announced on 5^th April, 2016.

A U.S. Food and Drug Administration (FDA) safety review has found that type 2 diabetes medicines containing saxagliptin and alogliptin may increase the risk of heart failure, particularly in patients who already have heart or kidney disease.

Heart failure can result in the heart not being able to pump enough blood to meet the body’s needs. As a result, a new warning is being added to the drug labels about this safety issue.

Saxagliptin and Alogliptin are part of the class of dipeptidyl peptidase-4 (DPP-4) inhibitor drugs, which are used with diet and exercise to lower blood sugar in adults with type 2 diabetes.

Patients taking these medicines should contact their health care professionals right away, if they develop signs and symptoms of heart failure such as:

• Unusual shortness of breath during daily activities
• Trouble breathing when lying down
• Tiredness, weakness, or fatigue
• Weight gain with swelling in the ankles, feet, legs, or abdomen

Patients should not stop taking their medicine without first talking to their health care professionals.

Health care professionals should consider discontinuing the medicine in patients who develop heart failure and monitor their diabetes control. If a patient’s blood sugar level is not well-controlled with their current treatment, other diabetes medicines may be required.

The original article can be accessed here.

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DPP-4 Inhibitors Used to Treat Type 2 Diabetes Mellitus may cause Joint Pain

FDA Issues Warning for DPP-4 Inhibitors; published in ClevelanD Clinic on 08.09.2015, drugs like sitagliptin, saxagliptin, linagliptin, and alogliptin, used to treat Type 2 Diabetes Mellitus, may cause joint pain that can be severe and disabling. Nevertheless, FDA has not advised to stop the medications.

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Fat in Dairy Food May Prevent Diabetes II

Diabetes
Generally diet experts deny dairy products to diabetics in fear of increasing the obesity from cholesterol. It has now been seen that a component of fat called trans-palmitoleic acid may actually help to prevent development of diabetes.
This fatty acid is not synthesized in the body, so needs external supplement. This commonly found in yogurt, butter, cheese and milk.
The cis part of palmitoleic acid, cis-palmitoleic acid is synthesized in body; and known to prevent development of diabetes. It is also seen that trans part of this fatty acid may help the cis part to have its effect translated.
Cis and Trans are two forms of the same molecule.

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Fat Cells May Be The Cause Of Diabetes II

Image via Wikipedia

There are many causes of diabetes especially type II diabetes mellitus. Amongst them obesity is most often pointed out to be a major cause for it. The fat cells called adipose cells, specially those present inside the abdomen, in the fatty apron called omentum are responsible for it. In one hand those consume insulin for their own metabolism and on the other hand can modify the protector genes. A gene identified in animals by researchers called Protein Kinase (PKC) C-Zeta, primarily responsible for down regulation of inflammation may act in a reverse way by promoting inflammation. They do so by producing IL6 (Interleukine6) which floods the liver to cause insulin resistance, where the glucose metabolism takes place.
More research in this field will show how that can be stopped or modified to reduce the incidence of diabetes II.   

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• http://www.nlm.nih.gov/medlineplus/news/fullstory_100744.html

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