Wednesday, June 2, 2010

Helicobacter Pylori Associated Diseases and Treatment

Dozens of the curved bacteria fill the lumen o...Image via Wikipedia
Curved Bacteria in the Lumen
Helicobacter Pylori, a gram negative bacteria, transmitted through feco-oral route, mainly in the under developed and developing countries. In late 80s, attention was drawn to the presence of this bacterium in many conditions. The association of H. Pylori has been seen in:
  • Gastritis, particularly in type B gastritis,
  • Duodenal and gastric ulcer,
  • Cancer of stomach and 
  • Mucosa associated lymphoma of stomach (MALT).
It attacks the gastric mucosa below the mucus cover and bicarbonate layer. There occurs mucosal atrophy, leading to gastritis and ulceration. The chronic inflammation may transform gastric mucosa to gastric cancer and lymphoma.
It can be detected from:
  • tissue biopsy examined under electron microscope and HP staining.
  • Presence of this bacterium can be detected from urea breath test,
  • Elisa blood test and 
  • some other tests.

Treatment comprises of multi-drug regime with many available alternative options: by far one of the best options is; Amoxicillin 500mgs, Clarithromycin 500mgs and pantoprazole 40mgs twice daily for one to two weeks followed by pantoprazole 40mgs for six weeks.  

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