- Girls aged 11 to 12 years should be routinely immunized using 3 doses of the HPV4 or HPV2 vaccine, administered intramuscularly at 0, 1 to 2, and 6 months.
- Girls and women aged from 13 to 26 years who have not been previously immunized or who have not completed their vaccinations should finish the series.
- Boys aged 11 to 12 years should be routinely immunized with HPV4, using the same schedule as for girls.
- Boys and men aged from 13 to 21 years who have not already been immunized or who have not completed their vaccines should finish the series.
- Men aged from 22 to 26 years who have not already been immunized or who have not finished the full series may be administered the recommended vaccine. (The AAP guidelines note that "cost-efficacy models do not justify a stronger recommendation in this age group.")
- Special efforts should be made to target use of the vaccine in gay or bisexual men up to 26 years of age who have not previously received the vaccine.
- People infected with HIV should be vaccinated or complete their series of vaccinations.
- The vaccine is not recommended during pregnancy, nor should it be administered to individuals with a known immediate hypersensitivity to yeast. However, it may be administered during lactation, as well as to those who are immunocompromised from either illness or medication.