Proton pump inhibitors are very
powerful inhibitor of acid secretion in stomach and can lower the
acidity (PH) inside stomach to a great extent.
The patients of gastroesophageal reflux
(GERD) disease, almost get addicted to this drug because it gives
them relief from considerable discomfort, the heart burn or burning
sensation inside the chest with reflux of contents of stomach.
But, continuous use of it can land the
person in a lot of problem as acid in stomach can not kill the
invading microbes; for which it is meant for.
The FDA warned today (08.02.2012) that
use of proton pump inhibitors (PPIs) may increase the risk of
Clostridium difficile associated diarrhoea, a hard to treat diarrhoeal
condition.
 |
| Image via Wikipedia; C. difficile |
Taking broad spectrum antibiotics can
kill the friendly bacteria present in the gut micro-flora to
dis-balance the normal micro-environment. Broad spectrum antibiotics
and PPI combination may cause havoc in the gut micro-flora.
The FDA advised healthcare providers to
consider a diagnosis of C. difficile-associated diarrhoea if
patients taking PPIs present with diarrhoea that is not improving and
said patients should take the lowest dose of PPI for the shortest
time possible to improve the condition being treated.
The agency is working with the drug makers to modify the labels to
include the possible risk of C. difficile-associated diarrhoea.The warning applies to the following PPIs, both prescription and over-the-counter:
- rabeprazole sodium
- dexlansoprazole
- esomeprazole magnesium
- omeprazole
- lansoprazole
- pantoprazole
The FDA is also reviewing the possible risk of in C. difficile-associated diarrhea in users of another class of acid suppressing medications, the histamine H2 receptor blockers.
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