Tuesday, October 16, 2012

Fat Cell Response to Insulin Decreased in Sleep Deprived State

Sleep, as generally perceived is required to give brain adequate rest. Now, it has been shown by a group of researchers lead by Matthew Brady, PhD, associate professor of medicine and vice-chair of the Committee on Molecular Metabolism and Nutrition at the University of Chicago that sleep is essential for good functioning of fat cells.
It has been seen that sleep deprivation is associated with obesity, irritability, diabetes and heart attack. At cellular level fat cells normally play an important role in fat metabolism by storing it, and thereby cleaning the fat from circulation.

Main health effects of sleep deprivation (See ...
Main health effects of sleep deprivation (See Wikipedia:Sleep deprivation). Model: Mikael Häggström. To discuss image, please see Template talk:Häggström diagrams (Photo credit: Wikipedia)

Insulin supply and response of fat cells to it are essential step in storing fat, and also in releasing energy from fat break down. If the circulating fat in form of lipoprotein can not be efficiently cleared that may lead to deposit of fat in blood vessels leading to other complications like atherosclerosis.
The researchers have shown that in sleep deprivation state the fat cells called adipose tissue respond 30% less to insulin. Whether getting adequate sleep will restore the insulin sensitivity, reverse diabetes and stop other complications are need to be studied.
The original article published in the ScienceDaily can be accessed here.
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