Saturday, December 24, 2016

After supper walk a mile to burn more Fat!

The old saying, “after lunch rest a while, after supper walk a mile’ may hold good; a recent research, published in the Science Daily, suggests. 
The use of lipids/fats and glucose in muscle depends on the circadian rhythm and may have a role in metabolic disorders like obesity and diabetes. 
The research team performed a number of functional genomics studies that established the link between HDAC3 (Histone Deacetylase3) and the circadian clock. 
In normal mice, when the mouse is awake, the clock in the muscle anticipates a feeding cycle and uses HDAC3 to turn off many metabolic genes. This leads the muscles to use more carbohydrate. When the animal is about to go to sleep and anticipates a fasting cycle, the clock removes HDAC3. This leads the muscles to use more lipid. 
Although these studies were done in mice, the researchers speculate that human muscles most likely will follow the same cycle. The study opens the possibility of promoting body fat burning by increasing exercise activity during the periods in which muscles use lipid, which is at night for people. 
The master clock in the SCN (Suprachiasmatic Nucleus in Hypothalamus) drives circadian rhythms of behavior including the sleep-wake cycle and feeding patterns.
Overview of biological circadian clock in huma...
Overview of biological circadian clock in humans. Biological clock affects the daily rhythm of many physiological processes. This diagram depicts the circadian patterns typical of someone who rises early in morning, eats lunch around noon, and sleeps at night (10 p.m.). Although circadian rhythms tend to be synchronized with cycles of light and dark, other factors - such as ambient temperature, meal times, stress and exercise - can influence the timing as well. (Photo credit: Wikipedia)
Circadian rhythms are generated at the cellular level by a self-sustained molecular clock. Exposure to alternating cycles of light and darkness synchronizes the SCN clock, thereby aligning behavior with the solar cycle.
The SCN regulates rhythmic synthesis of endocrine factors, including the release of glucocorticoids, which can potentially synchronize peripheral clocks. Through its effects on feeding cycles, the SCN can also coordinate the timing of peripheral cellular oscillators.
In general, the primary function of clock control of processes is to prepare the cell/tissue for a predictable event before its onset; through regulation of metabolism, circadian clocks likely allow anticipation of daily fluctuations in energy demand and/or nutrient availability (e.g. increased physical activity during the awake phase).
Common behavioral/environmental risk factors for cardiometabolic diseases (e.g. food intake, physical activity, lighting, etc.) are known to influence circadian clocks in a tissue-specific manner, leading to the suggestion that circadian misalignment contributes toward obesity, diabetes mellitus, and cardiovascular disease. 
Losing body fat would be easier by exercising lightly and fasting at night. "It's not a bad idea to take a walk after dinner."


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