Tuesday, April 19, 2011

Re-perfusion damage Limitation

Very high magnification (400x) micrograph of a... Simple injection could limit damage from heart attacks and stroke

(PhysOrg.com) -- This weeks Early Edition of the Proceedings of the National Academy of Sciences (PNAS) will publish a fascinating new milestone achievement in the search for novel clinical therapies to significantly reduce the loss of tissue and organ-functions following the loss of blood supply in widespread and serious human pathologies such as heart attacks (myocardial infarction) and strokes (cerebral ischemia). This new therapy was also shown to significantly improve the outcome of transplant surgery and of any surgical procedure that involves the temporary loss of blood supply.

There is risk of more tissue reaction following re-establishment of blood supply to tissue temporarily cut off from blood supply. The enzyme Mannan Binding Lectin-Associated Serine Protease-2 (MASP-2) released during re-perfusion of tissue is responsible for triggering a pathway, can be effectively blocked by a molecule that is being tested.

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