|English: Ginger (Photo credit: Wikipedia)|
The active compounds like -gingerol, -gigenrol and -shogaol found in ginger induce relaxation of airway smooth muscles (ASM), thereby causing bronchodilatation.
Data show that ginger and its isolated active components, -gingerol, -gingerol and -shogaol relax ASM, and -gingerol attenuates airway hyperresponsiveness, in part by altering [Ca(2+)] regulation.
Cyclic adenosine monophosphate (cAMP) has a critical role in several physiological functions of body. A large number of studies have elucidated the fundamental role of cAMP in the cellular response to many hormones and neurotransmitters.
The level of intracellular cAMP is regulated by the balance between the activity of two types of enzyme: adenylyl cyclase (AC) and the cyclic nucleotide phosphodiesterase (PDE).
The active compounds in ginger and Vitamin D could potentially provide an effective add-on treatment for all asthma sufferers, reducing the amount of steroid-based medicines prescribed.