- increase in level of homocysteine, an intermediate metabolite of protein methionine is blamed as cause of the disease. It has a direct deleterious effect on brain cells, causes atherosclerosis of blood vessels, promotes amyloid B protein deposit in cells and increases degradation of the neurotransmitter acetylcholine by up-regulating the activity of acetylcholinesterase especially, Butyrylcholinesterase.
3. Roshni George and Donald Graves, scientists at University of California - Santa Barbara, found that two compounds in cinnamon - cinnamaldehyde and epicatechin - show some promise in the effort to fight the disease.
According to George and Graves,the compounds have been shown to prevent the development of the filamentous"tangles" found in the brain cells that characterise Alzheimer's.
- Second interesting research is on a cancer drug that dissolves the deposited bad protein (Amyloid Beta) in the brain cells or neurons. It has been seen in mice to be effective. The research was on mouse model carried out in University of Pittsburgh Graduate School of Public Health.
Still, it has not been tried in human and some other researchers have given opinion to contrary. However, more trials are coming up with this drug that may clear the position.