Lack of 'gatekeeper' protein linked to skin cancer

Basal Cell CarcinomaScienceDaily (2011-05-18) -- New research shows that a "gatekeeper" protein plays an important role in skin-cancer prevention in humans and lab mice. The protein, C/EBP alpha, is normally abundantly expressed to help protect skin cells from DNA damage when humans are exposed to sunlight. The research shows, however, that the protein is not expressed when certain human skin cancers are present.
Long term exposure to ultraviolet rays from sun light cause damage the DNA in skin cells to initiate cancer of skin. Those can be squamous cell carcinoma, basal cell carcinoma and melanoma.
But, it not clear what causes the "gatekeeper" to disappear to facilitate cancer growth.. 

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• Lack of 'gatekeeper' protein linked to skin cancer (eurekalert.org)
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